3 edition of The structure of calcitonin determined from the design, synthesis, and study of model peptides found in the catalog.
The structure of calcitonin determined from the design, synthesis, and study of model peptides
Gregory R. Moe
Written in English
|Statement||by Gregory R. Moe.|
|LC Classifications||Microfilm 85/4534 (Q)|
|The Physical Object|
|Pagination||ix, 132 leaves|
|Number of Pages||132|
|LC Control Number||85892935|
The design of this peptide was based on the minimal amyloidogenic recognition motif of the human calcitonin hormone, Asp-Phe-Asn-Lys-Phe, the first amyloidogenic pentapeptide identified. By substituting phenylalanine with DOPA, we obtained DOPA Cited by: 5. Abstract. Calcitonin gene-related peptide (CGRP) is an abundant 37 amino acid neuropeptide which was discovered in . It is an extremely potent vasodilator, causing noticeable effects on the human forearm when given in femtomole quantities .Author: David R. Poyner.
Start studying calcitonin. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Thus, presenting a model capable of predicting the activity of both classes of peptides with a large range of activities can be useful for future peptide design studies. To reach this goal, the 82 peptides with the experimental values of pIC 50 were used for model building and 15 remaining peptides with less‐accurate values of pIC 50 were put Cited by: 6.
Calcitonin is the drug of choice for the treatment of osteoporosis, which is the major indication. It is also used for the treatment of hypercalcemia and paget’s disease. Calcitonin Produced in: Sweden. Documents available: DMF, CEP. Calcitonin Specifications: Calcitonin_EU Calcitonin_US. Calcitonin Safety Data Sheet: Calcitonin Safety Data Sheet. Calcitonin Gene–Related Peptide CGRP is a 37–amino acid neuropeptide synthesized in the central and peripheral nervous systems by tissue-specific splicing of the primary RNA transcript of the calcitonin/CGRP gene. CGRP is a potent vasodilator via both direct (cyclic adenosine monophosphate on VSMCs) and indirect (NO release from.
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A Study of the Structure and Internal Dynamics of Calcitonin Gene-Related Peptide by And study of model peptides book Soranno for providing a model for the structure of CGRP in solution. Frank The focus of this work is on elucidating the structure and dynamics of calcitonin gene-related peptide, or CGRP.
Solid Phase Synthesis of Skin Calcitonin Gene-related Peptide. S-CGRP was synthesized by the solid phase method to confirm the proposed structure and to demonstrate that biological activities of the purified natural peptide reflected intrinsic properties.
General and Comparative Endocrinology, DOI: /ited by: The human calcitonin gene is expressed at elevated levels ectopically in lung carcinoma (Coombes et al., ), and at grossly elevated levels in medullary thyroid carcinoma (Milhaud et al., ). Elegant studies on the structure and expression of the rat calcitonin gene have resulted in Cited by: 6.
Calcitonin gene-related peptide immunoreactive sensory and motor nerves of the rat, cat, and monkey esophagus. Gastroenterology.
Feb; 88 (2)– Roos BA, Fischer JA, Pignat W, Alander CB, Raisz LG. Evaluation of the in vivo and in vitro calcium-regulating actions of noncalcitonin peptides produced via calcitonin gene by: A synthesis of the unit human calcitonin M is associated with the fragment condensation approach to complex peptides.
The book also reviews cyclodepsipeptide valinomycin based on the possible transport of a potassium ion through biological membranes by this substance and the synthesis of a. Request PDF | Calcitonin Gene-Related Peptides | This chapter discusses calcitonin gene-related peptide (CGRP). CGRP is a 37amino-acid peptide that belongs to a family of structurally related.
NMR investigations of structural and dynamics features of natively unstructured drug peptide - salmon calcitonin: implication to rational design of potent sCT analogs. Journal of Peptide Science19 (1), Cited by: Solution conformation of salmon calcitonin in sodium dodecyl sulfate micelles as determined by two-dimensional NMR and distance geometry calculations.
Biochemistry30 (43), DOI: /bia Ambrish Kumar, Jay D. Potts, Donald J. by: 1. Helv Chim Acta. ;51(8) [Human calcitonin. Structure of calcitonin M and D]. [Article in German] Neher R, Riniker B, Rittel W, Zuber by: The calcitonin-calcitonin-gene-related peptide (CGRP) gene complex encodes a small family of peptides: calcitonin, CGRP and katacalcin.
Calcitonin is a circulating hormone that prevents skeletal breakdown by inhibiting the resorption of bone by osteoclasts. CGRP, a potent vasodilator, is involved in normal regulation of blood by: Calcitonin gene-related peptide (CGRP) is a 37 amino acid neuropeptide belonging to the calcitonin (CT) family of peptides.
This family also includes amylin, the calcitonin receptor-stimulating peptides, and the adrenomedullins (AMs), and they are found in vertebrates from ﬁsh to mammals (Ogoshi et al., ). Figure 1 provides an align-Cited by: This book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides.
This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition. Cards cover the site of synthesis, primary & secondary functions, means, & control of secretion questions for Calcitonin (TCT).
This precursor has been identified by pulse-chaseexperiments, molecular weight determinations, biological activity measurementsand analysis of tryptic peptides.
Its molecular weight is about (calcitonin, about ) as determined by polyacrylamide gel by: The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism Article Literature Review in Bone 43(5) August with Reads How we measure 'reads'.
This book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain : Hardcover.
Calcitonin (CT) was the first hormone reported to possess potent hypocalcemic activity resulting from the suppression of osteoclastic activity.
In mammals, CT is secreted from the parafollicular cells or C cells of the thyroid gland. In non-mammalian vertebrates, these cells are located in the ultimobranchial gland. Calcitonin is a membered heterodetic cyclic peptide comprising the sequence Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 cyclised by a disulfide bridge between the two Cys residues at positions 1 and has a role as a metabolite and a bone density conservation agent.
Design, synthesis, and characterization of a model peptide having potent calcitonin-like biological activity: implications for calcitonin structure/activity. Biochemistry. Apr 9; 24 (8)– Taylor JW, Miller RJ, Kaiser ET. Structural characterization of beta-endorphin through the design, synthesis, and study of model by: Jacobs J.
W., Goltzman D., and Habener J. F. () Absence of detectable calcitonin synthesis in the pituitary using cloned complementary deoxyribonucleic acid probes. Endocrinology–Author: Michael G. Rosenfeld, Stuart Leff, Susan G. Amara, Ronald M. Evans.Development of a novel antibody to Calcitonin Gene-Related Peptide for the treatment of osteoarthritis-related pain April Osteoarthritis and Cartilage 22(4).